Linear Peptide Synthesis | Customized Linear Peptides | High Purity Linear Peptides | Science-Peptide
Meta Description
Need high purity linear peptides?Science-Peptide's Linear Peptide Synthesis service covers 2-189 amino acids, 200+ modifications to choose from, milligrams to kilograms, fast delivery in 10-15 business days. Inquiries are welcome.
What are linear peptides?
A linear peptide is an amino acid that is connected to the end of the amino acid line, without a cyclic structure. Signal peptides, antimicrobial peptides, membrane-penetrating peptides, and precursors to cyclic peptides are all linear peptides.
Linear Peptide Synthesis sounds basic, but when it comes to doing it, there are a lot of potholes - long sequences are easy to aggregate, hydrophobic peptides run out of steam when purified, and sites with modifications can't be done in the right place. We have stepped on these potholes before, and we know how to get around them.
1. Length: 2 to 189 Amino Acids
|
Length |
Frequently Asked Questions |
What are we gonna do about it? |
|
Short peptides (2-15) |
It's basically a no-brainer |
Conventional synthesis, high yield, suitable for high volume |
|
Medium and long peptides (15-50) |
More hydrophobic amino acids tend to aggregate |
Adjustment of solvent system, addition of solubilizing label |
|
Long peptides (50-100) |
Decreased synthesis efficiency, difficult to purify |
Segment synthesis, selection of optimal segments for splicing |
|
Ultra-long peptides (>100) |
Something could go wrong at every step of the way |
Specialized protection strategies, up to 189 |
2. Purity: depending on what you're doing with it
- Crude (70-85%): for initial sieving, see which ones are active first, save cost.
- Routine pure (85-95%): most cell experiments, cost-effective.
- High purity (95-98%): animal experiments, functional verification, more reliable results.
- Ultra-pure (>98%): crystal structure, NMR, purity Raman.
- Each peptide is accompanied by HPLC and MS report, the purity is what it is. We do Linear Peptide Synthesis, we don't play around.
3. Modifiers: over 200, you name it, we've got it
- Fluorescent labeling:FITC, TAMRA, Cy5, see how the peptide enters the cell.
- Affinity labeling: biotin, His tag, for purification or detection.
- Stability modifications: PEGylation, fatty acids, extended half-life.
- Post-translational modifications: phosphorylation, glycosylation, acetylation, mimicking the real state.
- Special amino acids: D-type, unnatural, isotopically labeled (15N, 13C).
- End modification: amidation, acetylation, free acid, on demand.
- Whichever modification your Linear Peptide Synthesis needs, we've done it.
Why call us for Linear Peptide Synthesis?
1. We've been doing this for 20 years
Linear peptide synthesis is a basic skill, but there are different shades of basic skills. Transmembrane peptides, amyloid peptides, precursors with several disulfide bonds - we have seen a lot of peptides that are difficult to synthesize over the years. We have a good idea of which sequences are prone to problems and which conditions can save them. In Linear Peptide Synthesis, experience is something that can't be accumulated in a day or two.
2. There is more than one route
Depending on your peptide and dosage, we'll help you choose:
- Solid phase synthesis: conventional choice, short cycle time, suitable for most linear peptides.
- Liquid phase synthesis: long peptides or large quantities, lower cost.
- Solid-liquid hybridization: solid-phase for difficult fragments, followed by liquid-phase splicing to balance quality and cost.
- We don't just push one technology, we do the math for you: which is the most cost-effective path for your Linear Peptide Synthesis.
3. Quality control without confusion
- MS to see if the molecular weight is right.
- HPLC to see if the purity is enough.
- Peptide content, endotoxin, moisture, amino acid analysis - add as needed.
- Doing Linear Peptide Synthesis, the data speaks for itself, every peptide is well documented.
4. Delivery time speaks for itself
Standard peptides (<30aa, unmodified) 10-15 working days. The fastest time for expediting is 5 days. For long peptides or peptides with modifications, we will evaluate the peptide before reporting the lead time, and we will actively synchronize the progress in the middle so that you won't have to wait for the peptide. Choose our Linear Peptide Synthesis, delivery is not a problem.
5. From small to large quantities, without changing suppliers
Milligrams in the experimental stage, grams in the preclinical scale-up, kilograms in the production - we can handle it all. The same project, the same counterpart, eliminating the trouble of re-integration. We can follow your Linear Peptide Synthesis all the way to the end.
Where Can Linear Peptides Be Used?
|
Research directions |
Common needs |
What we can do |
|
Drug screening |
A batch of analogs to measure the activity of |
High-throughput synthesis, rapid delivery |
|
Cell-penetrating peptides |
With markers to see ingestion |
FITC/TAMRA labeling, purity >95%. |
|
Antimicrobial peptides |
Sequences with high sieve activity |
Controlled purity, batch consistency |
|
Signaling pathways |
Substrate peptides, inhibitors |
May be phosphorylated, acetylated |
|
Structural biology |
NMR, crystal |
High purity, isotopically labeled |
|
Immunology |
Antigenic peptides, epitope localization |
Biotin-labeled for ELISA |
|
Materials science |
Self-assembling peptides |
Sequential precision control |
No matter where your Linear Peptide Synthesis is used, we have a solution for you.
Delivery And Quality Control
- Delivery form: lyophilized powder, centrifuge tubes or vials.
- Accompanying document:COA (HPLC profile + MS spectrum).
- Optional tests: peptide content, endotoxin, moisture, amino acid composition.
- Customized Packaging:Dispensing, labeling, mixing as per your requirement.
- Each Linear Peptide Synthesis product is reviewed prior to shipment.
Three true stories
Case 1: Antimicrobial peptide program of a research institute
Asked for 30 linear peptides of 10-20aa to screen for antimicrobial activity. delivered in 2 weeks, all >90% pure. They screened 5 positives and published the article later. This Linear Peptide Synthesis program saved them at least a month of waiting time.
Case 2: Permeable peptide research by multinational pharmaceutical companies
A 25aa membrane-penetrating peptide with FITC labeling. The sequence is hydrophobic, so it is easy to be aggregated during synthesis. We added a temporary solubilizing tag and removed it after purification, and finally the purity was >95% and the labeling efficiency was high, so the cell experiment was completed smoothly. The customer said that the quality of this Linear Peptide Synthesis is much more stable than that of their previous supplier.
Case 3: Structural Biology Subjects at a Domestic University
We want a 15N-labeled linear peptide to do NMR, introduce isotopes accurately, and the purity is >98%, and the customer got a clear spectrum and solved the structure. We are experienced in this kind of demanding Linear Peptide Synthesis.
Talk about your needs?
Whether it's a few high-purity peptides for a critical experiment or a large batch synthesized for screening, you can talk. Choose Science-Peptide's Linear Peptide Synthesis service to accelerate your research.
I need you to tell me:
peptide sequences
How much to ask for (mg/g/kg)
purity requirements
To trim or not to trim
When do you want it?
Give you a quote and delivery plan within 24 hours.