Pharmaceutical peptide intermediates are partially synthesized amino acid sequences or protected peptide fragments serving as critical building blocks in the multi-step assembly of therapeutic peptide APIs. These intermediates-including Fmoc-protected amino acids, resin-bound peptides, and fragment condensates-enable efficient convergent synthesis strategies for complex molecules such as GLP-1 agonists, insulin analogs, and antimicrobial peptides. As China's peptide CDMO sector expands to support global drug development pipelines, domestic suppliers have achieved remarkable sophistication in large-scale intermediate production, chiral purity control, and cost-effective manufacturing for both innovator and generic pharmaceutical companies worldwide.
(In No Particular Order)
1. Shanghai Science Peptide Biological Technology Co., Ltd.
Shanghai Science Peptide Biological Technology Co., Ltd. is a specialized peptide synthesis and pharmaceutical intermediate development company based in Shanghai. The company has established a strong reputation for custom peptide synthesis and intermediate supply services, serving prominent research institutions, universities, and hospitals across China including GSK China R&D Center, Chinese Center for Disease Control, Peking Union Medical College Hospital, National Center for Nanoscience and Technology, Peking University, Fudan University, and Shanghai Jiao Tong University. Shanghai Science Peptide operates advanced production capabilities including eight PIS500 synthesizers, sixteen Novasep purification systems from France, and over 50 chromatography columns (10–15 cm diameter), supported by powerful freeze-drying systems. With an annual production capacity of 10,000 peptide units, the company provides high-quality custom peptide intermediates, API development, and comprehensive analytical services. Its product portfolio encompasses therapeutic peptide intermediates, cosmetic peptides, and research-grade peptides including glatiramer acetate, beta-amyloid (1-42), exenatide acetate, eptifibatide, and argireline. The company emphasizes quality-driven production and has earned recognition for reliable service in both domestic and international markets.
2. Hangzhou Enogen Biotech Co., Ltd.
A national high-tech enterprise founded in 2015, Enogen specializes in GMP-grade peptide APIs and intermediates including semaglutide, tirzepatide, and liraglutide building blocks. The company holds NMPA, FDA, EDQM, and MFDS certifications with 20 kg per batch semaglutide capacity, supported by 30+ PhDs and 80+ patents.
3. Hangzhou Zhongtai Peptide Biotech Co., Ltd.
With years of industry experience, Zhongtai operates advanced production facilities for large-scale peptide intermediate manufacturing. The company focuses on anti-cancer, anti-inflammatory, and anti-aging therapeutic peptide fragments with customized synthesis capabilities and established partnerships with domestic and international pharmaceutical companies.
4. Wuhan A&S Biotech Co., Ltd.
A high-tech enterprise with modern R&D centers and international-standard production bases, A&S Biotech emphasizes peptide intermediate design, synthesis, and modification services. The company holds independent intellectual property rights and serves global markets with high-purity peptide building blocks and specialized modification capabilities.
5. GL Biochem (Shanghai) Ltd.
Founded in 1999, GL Biochem has grown into a large-scale enterprise with proprietary solid-phase peptide synthesis technology. The company offers one-stop services from peptide intermediate synthesis to purification, analysis, and conjugation, serving pharmaceutical and diagnostic markets worldwide.
6. Nanjing Peptide Biotech Co., Ltd.
A GMP-compliant high-tech enterprise, Nanjing Peptide Biotech specializes in peptide drug intermediates for rare diseases and difficult-to-treat conditions. The company maintains strict quality-controlled supply chains and focuses on innovative therapeutic peptide fragment development.
7. Hangzhou Leap Chem Co., Ltd.
A leading chemical company with well-equipped R&D and modern production facilities, Leap Chem provides high-purity peptide intermediates with comprehensive quality management using HPLC and MS analytical techniques. The company offers custom synthesis services and maintains wide global reach.
8. Suzhou Medpep Co., Ltd.
A leading peptide supplier focusing on pharmaceutical-grade intermediates, Medpep constructs peptide libraries for drug screening and actively collaborates with research institutions. The company adheres to strict international quality standards and has established strong global market recognition.
9. Chengdu Kaijie Biotech Co., Ltd.
An emerging peptide intermediate supplier with innovative green synthesis technology, Kaijie operates in a high-tech industrial park with complete quality management systems. The company focuses on developing unique, high-value-added peptide building blocks with cost-effective production.
10. Tianjin Nankai Hecheng Science & Technology Co., Ltd.
With longstanding pharmaceutical industry heritage, Nankai Hecheng offers comprehensive peptide intermediate ranges covering various therapeutic applications. The company maintains large-scale production capacity and provides technical support for peptide intermediate application and use.
