Acetyl Hexapeptide-8 CAS 616204-22-9

Acetyl Hexapeptide-8 CAS 616204-22-9 | Carnosine-like Peptide | Anti-Wrinkle Cosmetic Ingredients | Kilogram Supply | Science-Peptide

Acetyl Hexapeptide-8 CAS 616204-22-9 (Carnosine-like Peptide) - the star ingredient of anti-wrinkle for dynamic wrinkles, Science-Peptide provides high purity Acetyl Hexapeptide-8, supports kilogram supply, stable batch, and has served many cosmetic companies. Welcome to contact us.

Acetyl Hexapeptide-8 (Acetyl Hexapeptide-8) is more commonly known in the cosmetic industry as "carnitine-like peptide". It is one of the most recognized and widely used ingredients in anti-wrinkle cosmetic peptides. From the international brands to the national newcomers, from the thousand dollar essence to the hundred dollar cream, can see its figure.

 

Its mechanism of action is very clear: by inhibiting the formation of SNARE complex, reduce the release of neurotransmitters, so that the amplitude of muscle contraction becomes smaller, so as to fade the expression lines. To put it plainly, it makes the wrinkles "stretch" a little, but not like Botox so that the muscles can not move at all. It's gentle, effective and reversible, which is why it's a favorite among formulators.

 

We have been in the field of peptide synthesis for 20 years, and Acetyl Hexapeptide-8 is one of our fist products, with mature technology, stable quality, and stable supply of kilograms. Unlike the blue copper peptide which is a repairing peptide, Acetyl Hexapeptide-8 focuses on the improvement of dynamic lines, which is the "function bearer" in anti-aging products.

Acetyl Hexapeptide-8 (INCI name: Acetyl Hexapeptide-8), six amino acids, small molecular weight, good transdermal properties. It is designed to mimic the N-terminal fragment of SNAP-25, a synapse-associated protein, and is able to competitively inhibit the formation of the SNARE complex and reduce the release of acetylcholine, thus weakening muscle contraction.

Simply translated: when you make an expression, your muscles contract and a line is pushed out of your skin. Acetyl Hexapeptide-8 makes this line lighter, but it doesn't make the muscle completely immobile, so it looks like a "natural stretch".

Acetyl hexapeptide-8 is almost ubiquitous in cosmetic formulations:

• Anti-Wrinkle Essence: focusing on wrinkle reduction and firming
• Eye Cream: for crow's feet and expression lines under the eyes
• Cream: Anti-aging for the whole face, preventing dynamic lines
• Neck Cream: Improves the appearance of horizontal lines on the neck
• Mask: as a potent addition to enhance instant firmness

It is one of the anti-wrinkle peptides with the most clinical data and the highest consumer awareness. Formulators choose it not because the concept is new, but because of its stable efficacy, good compoundability and consumer recognition.

Acetyl hexapeptide-8 is the most widely used peptide in cosmetics, from the international first-line to the Chinese head of the brand, almost every family has products containing it.

1. Estee Lauder Line Sculpting Essence (United States)
Estee Lauder's "Perfectionist Pro" line sculpting serum, focusing on acetyl hexapeptide-8 + a variety of signal peptides, claiming that "fast firming and wrinkle reduction". This product in the high-end essence sales has been very stable, is Estee Lauder anti-aging line of core products. They use Acetyl Hexapeptide-8 as the main ingredient for the improvement of dynamic lines, compounded with a variety of peptides and firming ingredients.

2. Lancôme Elite Eye Cream (France)
Lancôme Essence line is a high-end anti-aging series, the eye cream added Acetyl Hexapeptide-8, with rose essence and hyaluronic acid, focusing on wrinkles and firming. The eye cream has a very good reputation among the thousand dollar eye creams, and Acetyl Hexapeptide-8 is an important support for its anti-aging effect.

3. SK-II Big Red Bottle Cream (Japan)
Acetyl Hexapeptide-8 is also found in SK-II's R.N.A. Power Cream (Big Red Bottle), which has PITERA at its core but uses Acetyl Hexapeptide-8 in the anti-aging part to improve the appearance of dynamic lines. The fact that a major brand chose it shows that the ingredient has proven compatibility and stability.

4. Perrier Ruby Extract (China)
Perrier Ruby Essence is a national anti-aging essence in the explosion, the core ingredient is acetyl hexapeptide-8 (concentration to give a very sufficient) and supramolecular vita A alcohol, the main "peptide A combination". This product in the national product sales is very high, proving that acetyl hexapeptide-8 in the national product formula is also the main ingredient.

5. Marumi Red Pen Eye Cream (China)
Marumi's Red Pen Eye Cream features Acetyl Hexapeptide-8 + Dipeptide-2 + Acetyl Tetrapeptide-5, a three-peptide complex that targets all kinds of lines and puffiness around the eyes. Marumi is an expert in eye care, and the fact that they chose Acetyl Hexapeptide-8 as the main anti-wrinkle ingredient shows that the effectiveness of this ingredient in eye care is recognized.

6. HFP oligopeptide stock solution (China)
Although HFP's Oligopeptide Liquid is based on Oligopeptide-1, many of their products are also formulated with Acetyl Hexapeptide-8 for "anti-wrinkle and firming". As an ingredient brand, HFP's choice of formulas speaks volumes about the status of their ingredients in the industry.

From Estee Lauder and Lancôme at the thousand-dollar level to L'Oreal and Pelletier at the hundred-dollar level, Acetyl Hexapeptide-8 spans different price ranges. It is not a "noblewoman's exclusive", but a clear efficacy, cost-effective anti-wrinkle ingredients.

The application of Acetyl Hexapeptide-8 is very mature, and it can be compounded with various dosage forms and ingredients. We have organized several mainstream dosage forms for formulators' reference:

1. Acetyl Hexapeptide-8 Anti-Wrinkle Essence (Classic Dosage Form)
This is the most classic dosage form of Acetyl Hexapeptide-8, which is refreshing and easy to be absorbed, and is suitable for the whole face to fight against wrinkles.

Precautions:Acetyl hexapeptide-8 has good compatibility and can be compounded with most ingredients. Avoid prolonged high temperature heating, and it is recommended to add it in the cooling phase (below 50℃).

2. Acetyl Hexapeptide-8 Eye Cream (for eye area)
The skin around the eyes is thin and has a lot of dynamic lines, so Acetyl Hexapeptide-8 is a regular feature in eye creams.

The combination of dipeptide-2 and caffeine in this eye cream is a classic combination for the eye area. Acetyl Hexapeptide-8 is responsible for dynamic lines, Dipeptide-2 is responsible for puffiness, and Caffeine is responsible for circulation.

1. Stable supply of kilogram-scale capacity
Acetyl hexapeptide-8 is one of the largest varieties of cosmetic peptides, a pop-up product may use up dozens of kilograms or even hundreds of kilograms a month. We have amplified the process to run through, can be a stable supply of kilograms of products, and constantly supply.

2. Stable purity and consistency from batch to batch
The fluctuation of raw materials from batch to batch is the most feared in cosmetic formulations, which affects the skin feel and efficacy of the products. We do HPLC purity test for every batch of Acetyl Hexapeptide-8 to ensure the purity is stabilized above 98%. The impurity profiles of successive batches are almost identical.

3. Proven activity
The efficacy of Acetyl Hexapeptide-8 depends on its active structure. We do MS molecular weight confirmation for every batch of products to ensure the sequence is correct. Some of our customers have used our peptide for cellular experiments, and the efficacy data is stable, which means that there is no problem with the activity.

4. Good adaptability of formulations
Acetyl Hexapeptide-8 has good water solubility, good compatibility, and can be compounded with most cosmetic ingredients. It is not picky about pH and temperature, so formulators can use it with ease.

5. Complete documentation
Provide COA report (purity, molecular weight, moisture, appearance), MS profile, HPLC profile, TDS, MSDS. stability data can also be provided if needed.

Acetyl hexapeptide-8 is well-matched and can be used with most ingredients. Common Compounding Ideas:
+Palmitoyl Pentapeptide-4 / Palmitoyl Tripeptide-1: Acetyl Hexapeptide-8 for dynamic lines, signaling peptide for collagen regeneration, synergistic anti-aging.
+ Sodium Hyaluronate: hydrates and moisturizes for a more visible anti-wrinkle effect.
+Vitamin A: The "Peptide A Combo", with Acetyl Hexapeptide-8 as a base and Vitamin A as a reinforcement, is a classic combination for anti-aging products.
+ Dipeptide-2 / Acetyl Tetrapeptide-5: A classic combination in eye creams, Acetyl Hexapeptide-8 for dynamic lines, Dipeptide-2 for puffiness and Tetrapeptide-5 for bags.
+Blue Copper Peptide: Acetyl Hexapeptide-8 anti-wrinkle, Blue Copper Peptide repair, anti-aging products for sensitive skin.
Acetyl hexapeptide-8 is stable in formulations as long as prolonged high temperature heating (above 80°C) is avoided. It is not as afraid of chelating agents as blue copper peptides, so there is more freedom of formulation.

Acetyl hexapeptide-8 is the "top stream" in anti-wrinkle peptide, from Estee Lauder, Lancôme to L'Oreal, Pelletier, the big national brands are used. We have been doing peptides for 20 years, and our Acetyl Hexapeptide-8 process is mature, quality is stable, and there is no problem in supplying kilograms of Acetyl Hexapeptide-8. If you are doing anti-wrinkle serum, eye cream, face cream, and need a stable supplier of Acetyl Hexapeptide-8, welcome to chat with us